Wouldn’t it be great if we could find a supplement that could prevent arthritis?
Researchers in Helsinki may be on the path with a published study.
◆︎ What is the role of hyaluronic acid in arthritis?
➡Hyaluronic acid provides lubrication inside the joint. It increases the slipperiness.
➡It also downregulates the genes that cause inflammation.
➡The enzymes that destroy the cartilaginous covering of the bone are also downregulated.
In addition to its role in arthritis, hyaluronic acid is also important in connective tissue, skin integrity, and wound healing.
◆︎ The study:
The researchers found that horses with osteoarthritis had lower levels of hyaluronic acid in their joints. They looked at the joint that had arthritis, as well as the corresponding joint in the other leg. The lower levels were true for the “bad” leg, as well as the “good” leg. What the study didn't identify was if the lower levels in the "good" leg were caused by overuse from protecting the "bad" leg, or if there were some other systemic factors in play.
◆︎ What are the implications of this?
Two things come to mind. First, is it possible to create a test that identifies the level of arthritis that a horse has? Although this is possible, it would require specialized lab equipment to develop it.
And most importantly, can supplementation with hyaluronic acid increase levels within the joint?
➡providing the benefits of reduced inflammation and
➡a reduction of the cartilage-degrading enzymes?
The research is simplistic and elegant, but the potential ramifications are huge. If hyaluronic acid can be beneficial, it can be life-changing for a horse. In humans, severe arthritis can be treated with a joint replacement. For horses, arthritis limits their potential. In cases of severe arthritis, quality of life becomes an issue.
◆︎ Work with your vet:
Other research has suggested that hyaluronic acid as an intra-articular injection may be beneficial to treat osteoarthritis. The jury is still out as to if oral supplementation can also be beneficial. But the aspect that has not been investigated is if hyaluronic supplementation can delay the onset of debilitating arthritis. More research is needed to answer these important questions.
We do the best that we can for our horses. Understanding arthritis is a part of that.
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Disclaimer: Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
©Joan Kulifay 2025